2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

PDF 0.95 MB

The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (253):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W874018
    SMARCA2 ligand-8 2933254-33-0
    SMARCA2 ligand-8 can be used as the ligand of target protein SMARCA2 for synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225).
    SMARCA2 ligand-8
  • HY-13001R
    Quizartinib (Standard) 950769-58-1
    Quizartinib (Standard) is the analytical standard of Quizartinib. This product is intended for research and analytical applications. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis.
    Quizartinib (Standard)
  • HY-161830
    CDK7 ligand 2 2603381-71-9
    CDK7 ligand 2 (Compound A6) is a CDK7 ligand. CDK7 ligand 2 can be used in the synthesis of PROTACs.
    CDK7 ligand 2
  • HY-168314
    BTK ligand 11
    BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621).
    BTK ligand 11
  • HY-168275
    TRIB2 ligand-1 2652012-89-8
    TRIB2 ligand-1 is a ligand of TRIB2 (Ligands for Target Protein for PROTACs). TRIB2 ligand-1 can be used for synthesis PROTAC TRIB2 degrader-1 (HY-168274).
    TRIB2 ligand-1
  • HY-169967
    AR ligand-31
    AR ligand-31 is a PROTAC target protein ligand that can be used to synthesize PROTAC AR Degrader-5 (HY-160547).
    AR ligand-31
  • HY-161655
    SOS1 Ligand intermediate-5 3043923-70-9
    SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).
    SOS1 Ligand intermediate-5
  • HY-170600
    Boc-Ala(Me)-H117
    Boc-Ala(Me)-H117 is the active control for the target protein ligand H117 (HY-170599) of PROTAC HP211206 (HY-170598).
    Boc-Ala(Me)-H117
  • HY-168299
    AR ligand-30 2505498-73-5
    AR ligand-30 is a target protein ligand for PROTAC Bavdegalutamide (HY-138641), which can be used in prostate cancer research.
    AR ligand-30
  • HY-168296
    AR ligand-29 88378-55-6
    AR ligand-29 is the target protein ligand of PROTAC VinclozolinM2-2204 (HY-161741), which can be used for cancer research.
    AR ligand-29
  • HY-159545
    SMARCA2/4-ligand-2 2568281-88-7
    SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.
    SMARCA2/4-ligand-2
  • HY-169978
    ER ligand-3
    ER ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). ER ligand-3 can be used for the synthesis of PROTAC ER Degrader-12 (HY-160264).
    ER ligand-3
  • HY-168697
    AR ligand-37
    AR ligand-37 is a PROTAC target protein ligand that can be used to synthesize BMS-986365 (HY-158101).
    AR ligand-37