2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (283):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168292
    BTK ligand 9 1709786-35-5
    BTK ligand 9 is a target protein ligand for BTK and can be used to synthesize PROTAC DD-03-171 (HY-122830).
    BTK ligand 9
  • HY-168965
    BTK ligand 15 2668225-98-5
    BTK ligand 15 is the target protein ligand of PROTAC BTK Degrader-13 (HY-168963). PROTAC BTK Degrader-13 can selectively degrade BTK.
    BTK ligand 15
  • HY-W539427
    BRM/BRG1 ligand 1 1893977-70-2
    BRM/BRG1 ligand 1 is a BRM/BRG1 ligand, and can be used for synthesis of PROTAC BRM/BRG1 degrader-1 (HY-168242).
    BRM/BRG1 ligand 1
  • HY-169988
    BRD9 ligand-5 2633634-64-5
    BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B).
    BRD9 ligand-5
  • HY-161931
    Demethyl-RSL3-boc 2375354-07-5
    Demethyl-RSL3-boc is a ligand for target protein for pROTAC.
    Demethyl-RSL3-boc
  • HY-161807
    DENV ligand 1 1628758-48-4
    DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806).
    DENV ligand 1
  • HY-161711
    CBP/p300 ligand 5
    CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia.
    CBP/p300 ligand 5
  • HY-159472
    SMARCA2/4-ligand-1 2411651-36-8
    2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
    SMARCA2/4-ligand-1
  • HY-10997R
    Ibrutinib (Standard) 936563-96-1
    Ibrutinib (Standard) is the analytical standard of Ibrutinib. This product is intended for research and analytical applications. Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.
    Ibrutinib (Standard)
  • HY-168671
    pan-KRAS ligand 1 2886012-31-1
    pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669).
    pan-KRAS ligand 1
  • HY-161598
    DYRK2 ligand 1
    DYRK2 ligand 1 is a target protein ligand of PROTAC DYRK2 degrader 1 (HY-161597). DYRK2 ligand 1 can be used to study cancer.
    DYRK2 ligand 1
  • HY-168305
    EGFR ligand-11 2550394-08-4
    EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640).
    EGFR ligand-11
  • HY-170314
    EA-89
    EA-89 is a potent and selective BRD9 inhibitor with antitumor activity. EA-89 is a Ligand for Target Protein for PROTAC. EA-89 can be used to synthesize PROTAC QA-68 (HY-150797).
    EA-89
  • HY-118271
    GNF-8625 1196546-33-4
    GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
    GNF-8625
  • HY-172369
    CARM1/IKZF3 ligand 1
    CARM1/IKZF3 ligand 1 is the inhibitor for CARM1 that can be used as the target protein ligand for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368).
    CARM1/IKZF3 ligand 1
  • HY-49319
    USP7-IN-14
    USP7-IN-14 is a Ligand for target protein for pROTAC.
    USP7-IN-14
  • HY-170599
    H117 99.27%
    H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206 (HY-170598). H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (Mpro) with an IC50 of 151.3 nM.
    H117
  • HY-143277
    HL-2 2766352-49-0
    HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis.
    HL-2
  • HY-168252
    BRM/BRG1 ligand 3 2933126-51-1
    BRM/BRG1 ligand 3 is a target protein ligand that can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251).
    BRM/BRG1 ligand 3
  • HY-159542
    SMARCA2 ligand-6 2408394-89-6
    SMARCA2 ligand-6 is a ligand for target protein for pROTAC.
    SMARCA2 ligand-6